血清炎症指数评估甲状腺癌预后的研究进展

Research advances in serum inflammation indexes for evaluating the prognosis of thyroid cancer

摘要:

血清炎症指数是一类基于外周血炎症相关细胞计数计算得到的新型标志物，能够反映机体的全身炎症状态。炎症在大多数恶性肿瘤的病理生理学中发挥着关键作用，长期慢性炎症最终会诱发肿瘤并促进其生长。大量研究发现，炎症指数与多种恶性肿瘤的预后及临床结局相关，并可作为预后评估的潜在血清标志物。近年来，甲状腺癌在全球范围内呈现出明显的上升趋势，不同病理类型的甲状腺癌预后差别显著，有关血清炎症指数与甲状腺癌预后的研究成为热点。本文综述了血清炎症指数对不同类型甲状腺癌患者生存情况、复发/转移和疗效的预测价值，以期为临床决策提供证据支持。

Abstract:

Serum inflammation indexes are novel biomarkers derived from the counting of inflammation-related cells in peripheral blood, which reflects the systemic inflammatory status of the body. Inflammation plays a pivotal role in the pathophysiology of most malignant tumors. Chronic persistent inflammation ultimately induces tumorigenesis and promotes its progression. Numerous studies have demonstrated that inflammation indexes are associated with the prognosis and clinical outcomes of various malignant tumors. The inflammation indexes can serve as potential serum biomarkers for prognostic assessment. In recent years, the global incidence of thyroid cancer has shown a significant increasing. There are significant differences in prognosis among different pathological subtypes. Consequently, it has become a hotspot of investigation on the relationship between serum inflammation indexes and thyroid cancer prognosis. This review summarizes the predictive value of serum inflammation indexes for survival outcomes, recurrence/metastasis, and treatment efficacy in different types of thyroid cancer. It will provide evidence for clinical treatment.