儿童腺样体肥大与血清钙、磷水平的相关性分析

Analysis of the relationship between adenoidal hypertrophy and serum levels of calcium and phosphorus in children

摘要:

目的 本研究旨在探讨儿童血清钙、磷水平与腺样体肥大之间的潜在相关性，并分析腺样体肥大患儿血清钙、磷水平的相关影响因素。方法 将2022年1月—2024年12月住院行手术治疗的353例腺样体肥大患儿作为研究组，另纳入同期因其他疾病住院的89例患儿作为对照组，回顾性分析两组患儿血清钙、磷检测结果及临床人口学资料，对比两组血清钙、磷水平差异，并分析腺样体肥大患儿血清钙、磷水平的相关影响因素。结果 研究组血清钙、磷平均浓度分别为（2.40±0.10）mmol/L、（1.67±0.16）mmol/L，对照组分别为（2.38± 0.09）mmol/L、（1.60±0.21）mmol/L。两组血清钙水平差异无统计学意义（P=0.141），研究组血清磷水平明显高于对照组，差异具有统计学意义（P=0.002）。不同腺样体肥大分度患儿的血清钙（F=0.886，P=0.498）、血清磷（F= 0.017，P= 0.983）水平比较，差异均无统计学意义。相关性分析显示，腺样体肥大患儿的体质指数（BMI）与血清磷水平呈正相关（r=0.554，P＜0.001）。血清磷水平受病程影响：病程＜1 年、1～2 年、>2年患儿血清磷分别为（1.66± 0.16）mmol/L、（1.68±0.14）mmol/L、（1.75±0.15）mmol/L，组间差异具有统计学意义（F= 7.287， P=0.001），血清磷水平随病程延长呈上升趋势。结论 腺样体肥大患儿血清磷水平显著升高；该指标与扁桃体肥大分度无明显关联，与患儿BMI呈正相关，且随发病病程延长逐渐增高，可为腺样体肥大的临床诊疗提供一定参考。

Abstract:

Objective To explore the correlation between serum levels of calcium and phosphorus and adenoid hypertrophy(AH) in children, and to analyze the factors influencing serum levels of calcium and phosphorus in children with AH.Methods A retrospective study was conducted on 353 children with AH who underwent surgical treatment between January 2022 and December 2024, forming the study group. Additionally, 89 children without AH admitted during the same period for other diseases were selected as the control group. Serum levels of calcium and phosphorus, along with clinical demographic data, were collected from both groups. Differences in serum calcium and phosphorus levels between the two groups were compared, and factors influencing these levels were analyzed.Results The serum calcium and phosphorus levels in the study group were (2.40±0.10) mmol/L and (1.67±0.16) mmol/L, respectively, while those in the control group were (2.38±0.09) mmol/L and (1.60±0.21) mmol/L. There was no statistically significant difference in serum calcium levels between the two groups (P=0.141), whereas serum phosphorus levels were significantly higher in the study group compared to the control group (P=0.002). Comparisons of serum calcium (F=0.886, P=0.498) and serum phosphorus (F=0.017, P=0.983) levels among children with different degrees of adenoidal hypertrophy showed no statistically significant differences. Correlation analysis revealed a significant positive correlation between body mass index and serum phosphorus levels in children with AH (r= 0.554, P<0.001). Disease duration influenced serum phosphorus levels: levels were (1.66±0.16) mmol/L for patients with disease duration <1 year, (1.68±0.14) mmol/L for 1~2 years, and (1.75±0.15) mmol/L for >2 years, with significant differences among the groups (F=7.287, P=0.001), indicating that serum phosphorus levels gradually increased with prolonged disease duration.Conclusions Serum phosphorus levels are significantly elevated in children with AH. This parameter is not clearly associated with the degree of tonsillar hypertrophy but positively correlates with body mass index and increases progressively over time, providing a valuable reference for clinical diagnosis and treatment of AH.