Abstract:Objective To investigate the clinical efficacy, complications, and recurrence of transoral CO? laser resection of lingual cysts under suspension laryngoscopy, and to provide evidence-based support for the standardized application of transoral laser therapy in lingual cysts. Methods A retrospective analysis was conducted on 34 patients with lingual cysts who underwent transoral CO? laser resection at the Department of Laryngology, Shandong Provincial ENT Hospital from January 2022 to June 2025. All patients underwent CO? laser resection under suspension laryngoscopy with general anesthesia and orotracheal intubation. Key technical steps included marking the resection margin, active decompression for large cysts, complete excision of the base, and immediate hemostasis. Perioperative recovery was observed, and regular follow-up was performed to evaluate efficacy and recurrence. Results The procedure was successfully performed in all 34 patients, with no intraoperative conversion to an open approach. Postoperative pathology confirmed benign cystic lesions, with stratified squamous epithelium being the most common lining. Postoperative recovery was favorable in all patients; no nasogastric feeding was required, and no complications such as intraoperative or postoperative hemorrhage, pharyngeal fistula, respiratory distress, or tracheotomy occurred. Follow-up ranged from 10 to 36 months. The overall primary success rate was 91.2% (31/34), with a recurrence rate of 8.8% (3/34). All 3 recurrent cases were previously treated at other hospitals, while none of the 29 primary treatment cases in our series recurred. Conclusion Transoral CO? laser resection of lingual cysts under suspension laryngoscopy is minimally invasive, safe, and effective, with rapid postoperative recovery and few complications. Attention to technical details such as cyst margin marking, active decompression, and complete excision of the cyst base can significantly improve the primary cure rate and reduce recurrence. This approach may serve as the preferred minimally invasive treatment for primary benign lingual cysts.