3D生物打印技术在鼻咽癌微球体模型构建中的应用及展望

Research and application progress of 3D bioprinting in nasopharyngeal carcinoma spheroid models

摘要:

鼻咽癌的治疗面临肿瘤异质性高、模型预测性差等瓶颈，传统二维培养和PDX模型难以模拟肿瘤微环境，而3D生物打印技术通过构建肿瘤-免疫共培养模型为深入探索肿瘤的生物学、药学筛选及精准化治疗提供了崭新的平台。当前，关于3D生物打印鼻咽癌微球体模型的研究仍处于初步阶段。本文将系统综述3D生物打印技术在鼻咽癌微球体模型构建中的核心技术、应用价值及转化潜力。

Abstract:

Nasopharyngeal carcinoma immunotherapy faces bottlenecks such as high tumor heterogeneity and poor model predictability. Traditional twodimensional culture and PDX models can hardly simulate the tumor microenvironment. In contrast, 3D bioprinting technology provides a novel platform for indepth exploration of tumor biology, drug screening, and personalized therapy by constructing tumorimmune coculture models. At present, research on 3Dbioprinted nasopharyngeal carcinoma spheroid models is still in the preliminary stage. This paper systematically reviews the core technologies, application value, and translational potential of 3D bioprinting in the construction of nasopharyngeal carcinoma spheroid models.