异种脱细胞真皮基质联合鼻底黏膜瓣修补鼻中隔穿孔的临床疗效

Clinical efficacy of heterogeneous acellular dermal matrix combined with nasal mucosal flap for repairing nasal septum perforation

摘要:

目的 探讨异种脱细胞真皮基质(HADM)联合鼻底黏膜瓣修补鼻中隔穿孔的临床疗效。方法 选取延边大学附属医院收治的10例鼻中隔穿孔患者,在全身麻醉鼻内镜下采用HADM联合鼻底黏膜瓣修补鼻中隔穿孔。术后进行随访,观察黏膜瓣存活及鼻中隔修复情况,并分析手术成功率。结果 10例鼻中隔穿孔患者均一次性修补成功,双侧鼻腔通气良好,鼻部症状完全消失。术后随访8周,鼻中隔黏膜愈合良好，未见穿孔复发,均未出现局部或全身反应。结论 鼻内镜下采用HADM联合鼻底黏膜瓣修补鼻中隔穿孔，是一种初步证实有效的治疗方法,手术操作简易,可以在临床中推广使用。

Abstract:

Objective The aim of this study was to evaluate the clinical efficacy of HADM (Human Acellular Dermal Matrix, HADM) combined with nasal mucosal flap for the repair of nasal septum perforation. Methods Ten patients with nasal septum perforation admitted to the Affiliated Hospital of Yanbian University were selected. The nasal septum perforation was repaired under general anesthesia via nasal endoscopy using HADM combined with nasal mucosal flap. Postoperative follow-up was performed to assess the survival of mucosal flaps and the success rate of surgery. Results All 10 patients with nasal septal perforation were successfully repaired in a single surgery.Bilateral nasal ventilation was excellent, and nasal symptoms completely disappeared. During the 8 weeks of follow-up, there was no perforation of nasal septum and no local or systemic reactions. Conclusions It is an effective treatment method for the repair of nasal septum perforation using HADM combined with nasal mucosal flap under nasal endoscopy. The surgical procedure is simple and can be widely adopted in clinical practice.