Abstract:Meniere’s disease (MD) and vestibular migraine (VM) are two clinically common vertigo disorders. Both conditions present with similar symptoms including vertigo, hearing loss, tinnitus, and aural fullness, leading to diagnostic challenges in early-stage differentiation. Currently, there is no highly specific diagnostic test or biological marker to differentiate between the two conditions. In clinical practice, clinicians primarily rely on the combination of diagnostic guidelines from the Bárány Society and comprehensive evaluation of temporal characteristics of symptoms, genetic predisposition, and supplementary examinations. This paper provides a comparative analysis of MD and VM regarding their pathogenesis, clinical manifestations, and diagnostic criteria. This review summarizes the therapeutic progress of both conditions, aiming to provide novel insights and directions for future research in this field.