血常规指标在腺样体和/或扁桃体肥大的睡眠呼吸障碍儿童中的变化分析

Analysis of changes in routine blood indices in children with sleep apnea with adenoid and/or tonsil hypertrophy

摘要:

目的:分析腺样体和/或扁桃体肥大(ATH)的睡眠呼吸障碍(SDB)儿童血常规指标变化的临床意义,为儿童SDB的病情评估和预后评价提供一定的科学依据。方法:选取2023年10月至2024年8月在大理大学第一附属医院耳鼻咽喉科住院治疗的60例诊断为SDB(伴有ATH)的患儿作为病例组,选取同时期于本院体检的60例健康儿童作为对照组,病例组儿童行腺样体和/或扁桃体切除术,术后3个月返院复查。分别对比SDB儿童与健康儿童、SDB儿童术前与术后的血常规指标的变化。结果:病例组和对照组儿童的WBC、N%、L%、MO%、EO%、BA%、N#、L#、MO#、EO#、BA#、RBC、HGB、HCT、MCV、MCH、MCHC、RDW-CV、RDW-SD、PLT、PCT差异无统计学意义(P＞0.05)；病例组MPV、PDW、P-LCR均高于对照组,差异具有统计学意义(P＜0.05)。病例组MPV、PDW、P-LCR与年龄均呈正相关(r=0.322,P＜0.05；r=0.376,P＜0.05；r=0.349,P＜0.05)。病例组儿童术前和术后的WBC、N%、L%、MO%、EO%、BA%、N#、L#、MO#、EO#、BA#、HCT、RDW-CV、PLT、PCT、PDW、P-LCR差异无统计学意义(P＞0.05)；术后RBC、HGB、MCH、MCHC、MPV较术前降低,差异具有统计学意义(P＜0.05)； MCV、RDW-SD较术前升高,差异具有统计学意义(P＜0.05)。结论:血常规可以作为一个简单可靠的实验室参数,辅助评估SDB的病情严重程度和评价治疗效果。

关键词:睡眠呼吸障碍;儿童;腺样体肥大;扁桃体肥大;血常规

Abstract:

OBJECTIVE: To analyze the clinical significance of changes in blood routine indexes in children with sleep-disordered breathing (SDB) with adenoid and/or tonsil hypertrophy (ATH), and to provide some scientific basis for the assessment of the condition and prognosis of SDB in children. METHODS: Sixty children diagnosed with SDB (with ATH) who were hospitalized in the Department of Otorhinolaryngology of the First Affiliated Hospital of Dali University from October 2023 to August 2024 were selected as a case group, and 60 healthy children who had a physical examination in the hospital during the same period were selected as the control group. The changes in blood routine indexes of SDB children and healthy children, and SDB children before and after surgery were compared, respectively. RESULTS: The differences in WBC, N%, L%, MO%, EO%, BA%, N#, L#, MO#, EO#, BA#, RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV, RDW-SD, PLT, and PCT between the children of the case group and the control group were not statistically significant (P＞0.05); the differences in MPV, PDW, P- LCR were higher than those in the control group, and the differences were statistically significant (P < 0.05). MPV, PDW, and P-LCR were positively correlated with age in the case group (r=0.322, P<0.05; r=0.376, P<0.05; r=0.349, P<0.05). The differences in WBC, N%, L%, MO%, EO%, BA%, N#, L#, MO#, EO#, BA#, HCT, RDW-CV, PLT, PCT, PDW, and P-LCR between preoperative and postoperative periods in the children of the case group were not statistically significant (P > 0.05); the differences in postoperative periods were lower than preoperative periods in RBC, HGB, MCH, MCHC, and MPV, and the differences were statistically significant (P < 0.05); MCV, RDW-SD were elevated compared with the preoperative period, and the difference was statistically significant (P < 0.05). CONCLUSION: Blood routine could be a simple and reliable laboratory parameter to assist in assessing the severity of SDB and evaluating the therapeutic effect.

Key words:sleep-disordered breathing ; children ; adenoid hypertrophy ; hypertrophy of tonsils ; blood routine