SLC7A11与头颈部鳞状细胞癌的关系

Association of SLC7A11 with head and neck squamous cell carcinoma

摘要:

溶质载体第7家族第11个成员(SLC7A11)是一种氨基酸转运蛋白，负责细胞外胱氨酸的吸收并交换谷氨酸。胱氨酸被还原为半胱氨酸，半胱氨酸是谷胱甘肽合成中的限速底物，参与保护细胞免受氧化应激的过程，对细胞的生长、繁殖以及代谢更新过程具有重要的作用。SLC7A11在各种人体组织中都有表达，而且在众多类型的癌细胞中，发现其呈现上调趋势。SLC7A11的表达在肿瘤的预后和耐药性机制中起到关键性作用，因此被视为潜在的治疗靶点。在本篇综述中，我们将探讨SLC7A11的结构、功能、SLC7A11表达及活性的调控因素，特别关注其在头颈部鳞状细胞癌(HNSCC)发展中呈现的作用，以及能否作为评估预后的生物标志物。

Abstract:

Solute carrier family 7 member 11 (SLC7A11) is an amino acid transport protein responsible for extracellular cystine uptake and the cystine/glutamate exchanger. Cystine is reduced to cysteine, a rate-limiting substrate in glutathione synthesis,which is involved in the process of protecting cells from oxidative stress. SLC7A11 plays an important role in cell growth, reproduction, and metabolic renewal. SLC7A11 is expressed in a variety of human tissues and has been found to be upregulated in many types of cancer cells. SLC7A11 expression plays a key role in tumor prognosis and the mechanisms of drug-resistance,which is therefore considered as a potential therapeutic target. In this review, we will explore the structure, function, and regulatory factors of SLC7A11 expression and activity. We will have a particular focus on its role in the development of head and neck squamous cell carcinoma (HNSCC) and whether it can be used as a biomarker to assess prognosis.