线粒体自噬对喉癌的调控机制及其研究进展

Regulatory mechanism of mitochondrial autophagy in laryngeal cancer and its research progress

摘要:

线粒体自噬是一种通过选择性自噬机制来清除受损或功能失调的线粒体，从而维持细胞内线粒体平衡以及线粒体质量控制。喉癌是头颈部鳞状细胞癌常见肿瘤之一，尽管经过几十年的不断发展，喉癌患者的发病率及死亡率有所下降，但晚期喉癌患者的预后仍没有得到明显改善。越来越多研究表明，线粒体自噬与肿瘤的发生、发展密切相关。线粒体自噬对肿瘤不仅具有抑制作用，它还可以促进肿瘤的生长。本文阐述了线粒体自噬的调控机制、线粒体自噬与肿瘤的关系、线粒体自噬与喉癌的最新进展等方面的研究，目的在于为喉癌治疗提供新的治疗方向和靶点，从而更好地改善患者的预后。

Abstract:

Mitochondrial autophagy is a mechanism that removes damaged or dysfunctional mitochondria through selective autophagy, thereby maintaining intracellular mitochondrial homeostasis as well as mitochondrial quality control. Laryngeal cancer is one of the common tumours of head and neck squamous cell carcinoma (HNSCC). Although the morbidity and mortality of laryngeal cancer patients have decreased after decades of continuous development, the prognosis of patients with advanced laryngeal cancer has not been significantly improved. More and more studies have shown that mitochondrial autophagy is closely related to the occurrence and development of tumours. Mitochondrial autophagy not only has an inhibitory effect on tumors, but also can promote tumour growth. This paper describes the research on the regulatory mechanism of mitochondrial autophagy, the relationship between mitochondrial autophagy and tumors, and the latest progress of mitochondrial autophagy and laryngeal cancer, etc. The aim is to provide new therapeutic directions and targets for the treatment of laryngeal cancer, so as to better improve the prognosis of patients.