2型固有淋巴细胞介导辅助型T细胞2免疫调控变应性鼻炎的研究进展

Research progress on ILC2-mediated Th2 immune regulation of allergic rhinitis

摘要:

变应性鼻炎(AR)是典型的2型免疫炎症性病，而辅助型T细胞2(Th2)和2型固有淋巴细胞(ILC2)产生2型细胞因子是2型免疫反应过程中的中心环节。ILC2能够在免疫失调早期被迅速激活，与相对后期活化的Th2细胞发挥协同作用，成为固有免疫与适应性免疫之间的桥梁，共同介导疾病的发展全过程。Th2与ILC2的协同作用构成了2型免疫反应中的复杂调控体系。本文旨在了解ILC2的激活与抑制机制，梳理先天ILC2和适应性Th2细胞之间的相互作用，并对二者在2型免疫反应中的关系进行分析，有助于进一步深入理解AR的发病机制。

Abstract:

Allergic rhinitis (AR) is a typical type 2 immunoinflammatory disease. The production of cytokines type 2 by Th2(T helper 2 cell,Th2) and intrinsic lymphocytes type 2 (ILC2) is the central link in the process of type 2 immune response. ILC2 can be rapidly activated in the early stage of immune dysregulation . ILC2 exerts a synergistic effect with Th2 cells that is relatively activated in the later stage, which can serve as a bridge between intrinsic and adaptive immunity in the entire process of disease development. The synergistic effect of Th2 cells and ILC2 constitutes a complex regulatory system in type 2 immune response. This paper reviews the interaction between innate ILC2 and adaptive Th2 cells and analyzes their relationship in type 2 immune responses. It will contribute to a further in-depth understanding of the pathogenesis of AR.