Abstract:Objective To explore the application of image navigation combined with low-temperature plasma in nasal skull base surgery and summarize our clinical experience. Methods A retrospective analysis was conducted on the clinical data of 7 patients with nasal skull base lesions treated via endoscopic image navigation combined with low-temperature plasma at the department of otolaryngology head and neck surgery, Nanjing Drum Tower hospital affiliated to Nanjing university medical school, from August 2017 to March 2022. Comprehensive evaluations were performed based on surgical treatment and postoperative outcomes. Results The lesions were accurately located under navigation guidance and smoothly removed using low-temperature plasma technology in all the patients. They were followed up for 33 to 87 months after operation, and no recurrence or symptom aggravation was observed. The surgical outcomes were satisfactory, and there were no serious postoperative complications such as orbital and intracranial ones. Conclusions For patients with nasal skull base lesions, the combination of image navigation and low-temperature plasma can improve surgical accuracy, reduce surgical risks, and effectively lower the occurrence of postoperative complications. which lays the foundation for precise treatment and also proves its effectiveness and feasibility in nasal skull base surgery.