血清超氧化物歧化酶活性水平与慢性鼻窦炎关系的研究

Association between serum superoxide dismutase activity and chronic rhinosinusitis

摘要:

目的探讨超氧化物歧化酶(SOD)在嗜酸性粒细胞浸润型慢性鼻窦炎(eCRS)及非eCRS中的活性水平及其分型的相关性。方法分析南昌大学第二附属医院2022年6月—2023年12月收治的286例慢性鼻窦炎(CRS)患者的临床资料，CRS的病理类型根据术后病理切片中嗜酸性粒细胞浸润数进行分类，将患者分为eCRS组(112例)和非eCRS组(174例)；并通过本医院的病历系统或检验系统收集患者的SOD检测结果。结果 SOD在eCRS组的活性水平为(190.048±19.098) U/mL，在非eCRS组中的活性水平为(206.117±27.215) U/mL，经比较两组患者SOD活性水平差异具有统计学意义(P<0.05)，且与CRS是否为eCRS的分型呈负相关(P<0.05)。结论 SOD的活性水平在eCRS患者中表达量更低，且SOD的活性水平与CRS中是否为eCRS的内在分型存在相关性。

Abstract:

Objective To explore the activity of superoxide dismutase (SOD) in eosinophilic chronic rhinosinusitis (eCRS) and non-eCRS and the correlation between its expression and the classification of chronic rhinosinusitis. Methods Clinical data of 286 patients with chronic rhinosinusitis (CRS) admitted to the second affiliated hospital of Nanchang university from June 2022 to December 2023 were retrospectively analyzed. According to the pathological types of chronic rhinosinusitis based on the number of eosinophils in postoperative pathological sections, the patients were divided into eCRS group (112 cases) and non-eCRS group (174 cases). Their test Results of SOD were collected through the hospital’s medical record system or laboratory system. Results The activity level of SOD in the eCRS group was (190.048±19.098) U/mL, and that in the non-eCRS group was (206.117±27.215) U/mL. The comparison between the two groups showed a statistically significant difference (P<0.05), and it was negatively correlated with the classification of chronic rhinosinusitis as eCRS (P<0.05). Conclusion The activity of SOD is lower in eCRS patients, and the activity of SOD is correlated with the intrinsic classification of chronic rhinosinusitis as eCRS.