鼻腔浆液黏液腺错构瘤的临床分析

Clinical analysis of nasal cavity seromucinous hamartoma

摘要:

目的 通过回顾鼻腔浆液黏液腺错构瘤(SMH)4例患者的临床资料，对该病的临床和病理特点进行分析总结。方法 4例患者中，男3例，女1例；年龄23~66岁，平均年龄39.75岁。主要症状是单侧鼻塞及脓涕，3例病变位于钩突，1例病变位于中鼻甲。结果 所有患者均行鼻内镜下病变切除术，术后病理诊断均为SMH，表现为黏膜下呈簇状或小叶状增生的浆液黏液腺、导管。免疫组化结果：CK7、CK19为弥漫性阳性，S100、p63、EMA为局灶性阳性。随访6~48个月，均未复发。结论 鼻腔SMH临床症状缺乏特异性，病理学表现独特，手术彻底切除病变是有效的治疗手段。

Abstract:

Objective To retrospectively analyze the clinical data of 4 patients with nasal cavity seromucinous hamartoma(SMH), which summarized the clinical and pathological characteristics of SMH.Methods There were 4 patients(3 males and 1 female). The four patients ranged from 23 to 66 years old,with an average age of 39.75 years old. The main symptoms of the 4 patients were unilateral nasal congestion and purulent discharge.Three lesions of the patients were located in the uncinate process,and one lesion in the middle turbinate.Pathological changes manifest was clustered or lobular proliferation of mucinous glands and ducts under the mucosa. Results All patients underwent endoscopic lesion resection, and the pathological diagnosis was SMH, manifest was clustered or lobular proliferation of mucinous glands and ducts under the mucosa. Immunohistochemical results:CK7 and CK19 are diffuse positive, while S100, p63 and EMA are focal positive. Followed up for 6 to 48 months, with no recurrence.Conclusions The clinical symptoms of nasal cavity SMH are lack of specificity, and the pathology of the SMH is unique. Surgical removal of the lesion is an effective treatment method.