Abstract:Objective To summarize the optimal surgical repair protocol by retrospectively analyzing the recovery of 112 patients after surgical repair of nasal septal perforation. Methods A clinical retrospective study method was used to collect data from 112 patients who were hospitalized in the Ninety-fourth Hospital of the United Logistics Force from 2003.01 to 2023.07 with confirmed diagnosis of nasal septal perforation and surgical treatment, and were followed up for at least 3 months after surgery. Comparison of preoperative and postoperative subjective symptom scores and objective nasal endoscopic sign scores was made and the two surgical approaches were compared in different perforation sizes. Results 112 patients underwent nasal endoscopic septal perforation repair, 22 patients were reviewed and found to have re-perforation or residual small perforation, 10 patients underwent secondary surgery, 1 patient underwent tertiary surgery, 4 patients did not undergo further surgical treatment due to lack of willingness to undergo surgery, 7 patients were lost to postoperative visits and had an inconclusive outcome, and the rest of the patients achieved one-stage healing. There was a statistical difference between the preoperative and postoperative subjective symptom scores and objective sign scores (p < 0.05), and there was no statistical difference in the comparison of different perforation sizes between the two surgical methods (p > 0.05). Conclusion The optimal surgical method should be selected based on the size and location of the perforation.