肿瘤异质性对头颈部鳞状细胞癌进化模式的临床启示：叙述性综述

Harnessing tumor heterogeneity for clinical insights: A narrative review of evolutionary patterns in head and neck squamous cell carcinomas

摘要:

头颈部鳞状细胞癌（Head and neck squamous cell carcinoma, HNSCC）因其高度的异质性和复杂的进化动力学，一直是肿瘤学领域的一项重大挑战。本研究深入探讨了HNSCC的进化模式和肿瘤异质性，以揭示其错综复杂的病理格局。全面审视现有文献揭示了影响HNSCC肿瘤内异质性和克隆进化的遗传、表观遗传以及微环境因素的复杂相互作用。此外，本文还深入探讨了肿瘤异质性的临床意义，包括其对个性化治疗策略、生物标志物的发现以及利用液体活检技术进行疾病进展的非侵入性监测的影响。通过揭示HNSCC背后的分子和细胞层面的复杂性，本文旨在提供深刻的见解，为临床实践提供宝贵信息，以期改善患者的预后，并加深我们对HNSCC生物学的理解。

Abstract:

Head and neck squamous cell carcinoma (HNSCC) represents a major challenge for oncology due to its heterogeneity and complex developmental dynamics. This research addresses the intricate landscape of HNSCC by examining the evolutionary patterns and heterogeneity of the tumor. A comprehensive review of the current literature highlights the multifaceted interplay of genetic, epigenetic, and microenvironmental factors that drive tumour heterogeneity and clonal evolution in HNSCC. In addition, we explore the clinical implications of tumour heterogeneity, including its impact on personalised treatment strategies, biomarker discovery, and non-invasive monitoring of disease progression using liquid biopsy techniques. By unravelling the molecular and cellular complexity underlying HNSCC, this article aims to provide valuable insights that can inform clinical practice, improve patient outcomes, and deepen our understanding of HNSCC biology.