外泌体调节头颈部鳞状细胞癌上皮间充质转化的研究进展

Advances in exosomes regulating epithelial mesenchymal transformation in head and neck squamous cell carcinoma

摘要:

随着全球头颈部鳞状细胞癌(HNSCC)发病率的逐年增加及流行病学趋势的改变，以及面对HNSCC患者多于疾病晚期确诊且常伴有转移的现况，HNSCC在肿瘤微环境中发生转移的因素越来越受到关注。本文就外泌体在肿瘤进展中的细胞通讯作用、上皮间充质转化(EMT)在肿瘤进展中的作用、外泌体与EMT间的关系及外泌体在HNSCC EMT中的研究进展及其针对肿瘤EMT方面的临床应用前景进行综述，旨在探求在肿瘤微环境中外泌体对于HNSCC EMT的影响。

关键词:头颈部鳞状细胞癌;外泌体;上皮间充质转化;肿瘤转移

Abstract:

The incidence of head and neck squamous cell carcinoma(HNSCC) has been gradually increasing in the world. And more patients with HNSCC are diagnosed at advanced stages and often with metastases by epidemiological trend of HNSCC.The factors of HNSCC developing metastasis in the tumor microenvironment have attracted more and more attention. In this paper, we reviewed the cell communication role of exosomes and the role of epithelial mesenchymal transformation(EMT) in tumor progression, the relationship between exosomes and EMT, the research progress of exosomes in EMT of HNSCC, and the clinical application prospects of exosomes in tumor EMT. This paper provides the effect of exosomes on EMT in the tumor microenvironment of HNSCC.

Key words:Head and neck squamous cell carcinoma;Exosomes;Epithelial mesenchymal transition;Tumor metastasis