转移相关蛋白2在头颈部恶性肿瘤中的作用

Effect of MTA2 in head and neck malignant tumors

摘要:

转移相关蛋白2(MTA2)是近年来被发现的与肿瘤侵袭进展、转移相关的转录调控家族成员，在肿瘤的增殖、侵袭以及远处转移中起着非常重要的作用。其在多种头颈部恶性肿瘤如鼻咽癌、口腔癌、喉癌、食管癌、甲状腺癌中呈高表达，并且MTA2的高表达与这些恶性肿瘤的不良预后相关。MTA2与头颈部恶性肿瘤的侵袭、进展及预后的关系研究成为了头颈肿瘤研究中的新热点。本文对MTA2的结构与功能、其在不同头颈肿瘤中的表达以及意义、其可能的调节机制以及其研究展望作一个小结，希望对MTA2的后续研究以及头颈肿瘤的综合诊治提供帮助。

关键词:头颈部恶性肿瘤;转移相关蛋白2;综述

Abstract:

Metastasis associated protein 2 (MTA2) is a member of the transcriptional regulation family that has been discovered recently and is associated with tumor invasion, progression and metastasis, which plays a very important role in tumor proliferation, invasion and distant metastasis. MTA2 is highly expressed in a variety of head and neck malignancies, such as nasopharyngeal carcinoma, oral carcinoma, larynx cancer, esophageal cancer, thyroid cancer, and other malignancies. The high expression of MTA2 is associated with poor prognosis of these malignancies. The relationship between MTA2 and the invasion, progression and prognosis of head and neck malignant tumors has become a new hotspot in the research of head and neck tumors. This paper makes a summary of the structure and function of MTA2, its expression and significance in different head and neck tumors, its possible regulatory mechanism and its research prospect. We hope to provide some help for the follow-up study of MTA2 and the comprehensive diagnosis and treatment of head and neck tumors.

Key words:Head and neck malignant tumors;Metastasis associated protein 2;Summarize