14例阿司匹林耐受不良三联征临床分析

Clinical analysis of 14 patients with aspirin intolerance triad

摘要:

目的 探讨阿司匹林耐受不良三联征(AIT)的临床特点，治疗方法，总结最新诊疗经验。方法 采用回顾性研究方法, 对14例AIT患者的用药特点、临床特点、鼻窦CT、鼻镜、鼻腔鼻窦手术史等结果及治疗情况进行统计分析，并进行相关文献复习。结果 14例患者中1例患者因哮喘急性发作，经术前评估后暂缓手术治疗；13例患者行手术治疗，术后6个月随访，其中11例未见复发，病情基本得到控制；2例患者鼻部症状复发，1例再次行手术治疗，另1例继续药物综合治疗。结论 AIT因其伴有哮喘及相关药物过敏情况，鼻窦炎症状较重，多为全组鼻窦炎，易复发，远期失嗅，早期临床多误诊。能够早期明确诊断，早期围术期规范用药，早期进行彻底清除病灶，并进行规律术后药物治疗是本病的治疗关键。

Abstract:

Objective To explore the clinical characteristics and treatment methods of aspirin intolerance triad (AIT), summarize the cutting-edge research at home and abroad, and summarize the latest diagnosis and treatment experience.Methods A retrospective study was conducted to analyze the medication characteristics, clinical features, sinus CT, nasal endoscopy, history of nasal and sinus surgery, and treatment status of 14 AIT patients. Relevant literature was reviewed.Results One of 14 patients had an acute attack of asthma, and the operation was postponed after preoperative evaluation;11 cases of 14 patients were followed up for 6 months without recurrence, and the condition was basically under control; 2 patients of 14 patients had recurrent nasal symptoms, one of them underwent surgery again, and the other one continued drug combination therapy.Conclusions Due to its accompanying asthma and related drug allergies, AIT has severe symptoms of sinusitis, which is mostly a complete group of sinusitis, prone to recurrence, long-term loss of smell, and early clinical misdiagnosis.The key to the treatment of this disease is to have a clear diagnosis in the early stage, standardize medication during the perioperative period, thoroughly remove the lesion in the early stage, and provide regular postoperative medication treatment.