Abstract:Nasopharyngeal carcinoma (NPC) is a highly occurring malignant tumor in China, and about three-quarters of patients are diagnosed with local advanced stage. Radiotherapy and systemic chemotherapy are currently important treatments for patients with NPC, and the prognosis of patients is not optimistic. Therefore, improving the prognosis of NPC patients is an urgent problem to be solved clinically. Recently, the latest research has found that a new regulatory cell death mode cuprotosis, which has reduced drug resistance in tumor treatment to a certain extent, and which possesses great potential in tumor prevention and treatment. Therefore, this paper will summarize the activation mechanism of cuprotosis-related anti-cancer and its research progress in NPC, which provides a new basis for NPC treatment.