Abstract:Nasopharyngeal carcinoma(NPC) is a kind of head and neck malignant tumor closely related to Epstein-Barr virus infection, and its pathogenesis has not been fully elucidated. Radiotherapy is the main treatment for nasopharyngeal carcinoma, while radio-resistance is easy to cause tumor recurrence or metastasis and ultimately lead to radiotherapy failure. Ataxia-telangiectasia mutated (ATM) gene is mainly activated when DNA double-strand breaks. ATM can participate in the regulation of DNA damage repair, cell cycle arrest and apoptosis. Studies have shown that ATM plays different roles in different stages of NPC development and in the process of therapeutic intervention. ATM also plays an important role in the radio-resistance of NPC. In recent years, a method for reducing the radio-resistance of tumors by inhibiting ATM activity has become a research hotspot. This paper briefly reviews the role and research progress of ATM-related signaling pathways in NPC, which will provide reference for the treatment of NPC.
