Abstract:Sensorineural hearing loss (SNHL) is the most common form of hearing loss. Previous studies mainly focused on ototoxicity, noise, aging, autoimmune disorders and other causes, exploring oxidative stress damage caused by reactive oxygen species or series of molecular biological changes caused by gene variation, leading to apoptosis of sensorinear nerve cells, resulting in hearing impairment or loss. However, the pathogenic mechanism of SNHL has not been fully understood. In recent years, the rapid development of proteomics technology has provided new methods and theories for further revealing the related factors and regulatory pathways of sensory nerve cell death. This paper reviews the research progress of proteomic techniques in the pathway or mechanism of sensorineural cell death and therapeutic targets, which will provide reference for the prevention and treatment of SNHL.
