Abstract:The pathogenesis of allergic rhinitis (AR) is complex, and the neuro-immune mechanism is an important discovery. The central nervous system (CNS) receives immune inflammatory signals from the periphery, integrates and transmits them to the peripheral target organs, and realizes the precise regulation of the immune system, which constitutes the central-peripheral bidirectional network of allergic rhinitis. It plays an essential role in the nerve terminals innervating the nasal mucosa interact with core immune cells such as mast cells(MC), eosinophils(EOS), and type 2 inherent lymphocytes (ILC2s) by releasing neuropeptides to form the peripheral neuro-immune network of AR pathogenesis. Neuropeptides such as substance P, procalcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), neurointerleukin U (NMU) and neuropeptide Y (NPY) play an important role. In this paper, the neuro-immune mechanism of AR and the mechanism of neuropeptides on immune cells and their research progress are reviewed.
