鼻腔鼻窦窦组织细胞增生症伴巨大淋巴结病的临床病理特征分析

Analysis of clinicopathological features of sinus histiocytosis with massive lymphadenopathy

摘要:

目的 探讨发生在鼻腔鼻窦的窦组织细胞增生症伴巨大淋巴结病(SHML)的临床、病理特征。方法 报道3例鼻腔鼻窦SHML患者的临床资料，总结分析其临床病理特征并进行相关文献复习。结果 发生在鼻腔鼻窦的SHML临床以鼻塞为主。病理组织学特点为在淋巴、浆细胞背景下，可见弥漫浸润的窦组织细胞，局部见“封入”现象。免疫组织化学染色示肿瘤细胞表达CD68、S-100。结论 SHML是一种组织细胞增生性病变，发生在鼻腔鼻窦的SHML非常罕见，临床表现缺乏特异性。病理学诊断为金标准，以手术治疗为主，但效果不佳。

Abstract:

Objective To analyze the clinical and pathological features of sinus histiocytosis with massive lymphadenopathy (SHML) in the nasal cavity and paranasal sinus.Methods The clinical data and clinicopathological features of 3 patients with SHML were reported and reviewed.Results Nasal congestion is a mainly symptom of the clinical features of SHML. The phenomenon of “sealing” was observed in the sinus histiocytes with diffuse infiltration of lymph and plasma cells, which was a histopathological feature of SHML. Immunohistochemical staining showed expressions of CD68 and S-100 in tumor cells.Conclusions SHML is a kind of histiocytoproliferative lesion.SHML occurring in the nasal sinuses is very rare and its clinical manifestations lack specificity. The pathological diagnosis is the gold standard and SHML is mainly treated by surgery, but its curative effect is poor.