Abstract:Objective To investigate the predictive value of peripheral blood B-cell activating factor (BAFF) on the severity of allergic rhinitis (AR).Methods Eighty patients with AR admitted to our hospital from January 2019 to October 2019 were selected as the AR group, and they were subdivided into mild and moderate-severe groups according to symptom scores. Meanwhile, 50 patients without AR hospitalized due to nasal bone fracture or septoplasty were selected as the control group. The expression levels of serum BAFF in different groups were analyzed and compared. The predictive value of serum BAFF level on the severity of AR was analyzed by receiver operating characteristic curve.Results Serum BAFF level of the AR group was significantly higher than that of the control group (P<0.05). Compared with the mild AR subgroup, serum BAFF level got significantly elevated in the moderate-severe subgroup, and the difference was statistically significant (P<0.05). Serum BAFF level was positively correlated with peripheral blood eosinophil number and ratio, total immunoglobulin E level, visual analogue scale score and total nasal symptoms score in the AR patients. ROC results showed that serum BAFF had certain advantages in distinguishing the diseases of AR patients compared to total immunoglobulin E level, with a sensitivity of 0.550 and a specificity of 0.825.Conclusion Elevated peripheral blood BAFF level in AR patients correlates with the degree of eosinophilic inflammation, and can be used as a marker to predict the severity of AR.
