Objective To investigate the etiology and surgical treatment of primary empty sella syndrome.Methods Seven patients in a single center from 2011 to 2023 were treated by means of transsphenoidal microscopic or endoscopic sellar floor dura lifting. Among them, 2 were males and 5 were females, aged 24-70 years, with an average age of 48.3 years. Their preoperative clinical symptoms included headache and ophthalmic symptoms of decreased vision and visual field.Results Headache and ophthalmic symptoms disappeared after surgery, and no postoperative complications occurred in all patients.Conclusions The pulsation of internal carotid artery with the optic nerve and the dura leads to a series of headache and ophthalmic symptoms. The operation to lift the sellar floor dura is an effective treatment for primary empty sella syndrome.