Abstract:Endoplasmic reticulum (ER) is an important organelle in eukaryotes to maintain normal cell function and the stability of the internal environment. When ER homeostasis is disrupted, such as excessive protein processing load, insufficient nutrition supply, virus infection and redox imbalance, endoplasmic reticulum stress (ERS) will occur. It will lead to Ca2+ imbalance, endoplasmic reticulum overload, activation of apoptotic pathway and other abnormal reactions. ERS affects the expression of some important proteins, induce inflammation and participate in cell apoptosis, which leads to the occurrence of many chronic inflammatory and autoimmune diseases. Previous studies have confirmed that ERS is involved in the pathogenesis of obesity, neurodegenerative diseases, diabetes, pulmonary fibrosis and other diseases. Regarding the role of ERS in airway allergic inflammatory disease (AAID), there are some latest research results at home and abroad. This paper will review the immune regulation mechanism mediated by ERS, and further explore the possible role of ERS in the pathogenesis of AAID. It provides new ideas for future research and treatment strategies of related diseases.
