气道慢性炎症与慢性鼻窦炎中PPARγ和ILC2s关系的研究进展

Research progress on the relationship between PPARγ and ILC2s in chronic airway inflammation and Chronic rhinosinusitis

摘要:

Ⅱ型固有淋巴样细胞(ILC2s)是一种非B、非T的新型淋巴细胞，可以产生大量促炎和调节性细胞因子，以应对局部损伤、炎症、病原体感染或肿瘤。过氧化物酶体增殖物激活受体γ(PPARγ)属于细胞核激素受体超家族配体激活转录因子之一，与相应配体结合后调节细胞增殖、分化、代谢等，从而在炎症反应中发挥重要作用。PPARγ广泛分布在人类鼻黏膜及鼻息肉黏膜中，并通过作用于ILC2s上的抑制肿瘤发生受体(ST2)、程序性细胞死亡蛋白-1(PD-1)以及影响ILC2s的能量代谢等途径影响ILC2s的功能。本文就PPARγ与ILC2s的关系以及在气道慢性炎症及慢性鼻窦炎(CRS)中的表达及相互作用进行综述，从而为气道慢性炎症性疾病及CRS的发病机制及治疗提供新思路。

Abstract:

Type 2 innate lymphoid cells (ILC2s) is a new type of non-B, non-T lymphocytes that can produce a large number of proinflammatory and regulatory cytokines to deal with local damage, inflammation, pathogen infection or tumor. Peroxisome proliferator-activated receptor γ (PPARγ)belongs to one of the ligand-activated transcription factors of the nuclear hormone receptor superfamily. After binding with the corresponding ligand, it regulates cell proliferation, differentiation, metabolism, etc., thus playing an important role in inflammatory response. PPARγ is widely distributed in human nasal mucosa and nasal polyps mucosa. The function of ILC2s is affected by the action of suppression of tumorigenicity 2 (ST2), programmed cell death protein-1 (PD-1) and energy metabolism of ILC2s. This article reviewed the relationship between PPARγ and ILC2s, and their expression and interaction in chronic airway inflammation and Chronic rhinosinusitis(CRS), so as to provide new ideas for the pathogenesis and treatment of chronic airway inflammatory diseases and CRS.