Abstract:Chronic rhinosinusitis is one of the most common chronic inflammatory diseases of the upper respiratory tract, in which eosinophilic chronic rhinosinusitis (ECRS) has a high treatment resistance rate and recurrence rate. At present, its etiology and pathogenesis are still unclear. The establishment and application of the animal model of ECRS is an ideal means to study the pathological mechanism and treatment of this disease. Mice are commonly used as modeling animals. However, there is still a lack of a recognized mature and stable mouse model of ECRS in basic research. The stable mouse model of ECRS has become a key bottleneck in the analysis of the pathogenesis, drug screening, precise treatment, diagnosis and prognosis of the disease. This paper reviews the commonly used mouse models of ECRS, and a summary study on their modeling principle, methods and steps, evaluation index and model application, in order to provide methods and theoretical basis for the successful establishment of the mouse model and related experimental research.
