Abstract:ILC2s is a new type of non-B, non-T lymphocytes that can produce a large number of proinflammatory and regulatory cytokines to deal with local damage, inflammation, pathogen infection or tumor. PPARγ is one of the transcription factors activated by nuclear hormone receptor superfamily ligand , which regulates cell proliferation, differentiation and metabolism after binding to the corresponding ligand, thus playing an important role in inflammatory response. PPARγ is widely distributed in human nasal mucosa and nasal polyps mucosa, and affects the function of ILC2s by acting on ST2 and PD-1 on ILC2s and affecting the energy metabolism of ILC2s. This article reviews the relationship between PPARγ and ILC2s, and its expression and interaction in chronic airway inflammation and CRS, so as to provide new ideas for the pathogenesis and treatment of chronic airway inflammatory diseases and CRS.