Abstract:Objective To investigate the predictive value of preoperative clinical features for eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), and to construct a nomogram for clinical practice.Methods 97 patients with chronic rhinosinusitis with nasal polyps ( CRSwNP ) who underwent functional endoscopic sinus surgery in the First Affiliated Hospital of Xinxiang Medical University from September 2019 to September 2020 were selected,and were divided into ECRSwNP group and nonesinophilc chronic rhinosinusitis with nasal polyps ( nonECRSwNP ) group,According to the postoperative pathological results of eosinophils ( EOS ) infiltration.The clinical characteristics of the two groups were collected and compared. The univariate and multivariate binary logistic regression analysis was used to screen the preoperative characteristics with predictive value for ECRSwNP, and the nomogram for clinical practice was constructed. SPSS26.0 and R language software 4.1.2 were used to analyze the data.Results There were significant differences in the history of asthma, peripheral blood EOS%, peripheral blood basophil percentage (Baso%), Japanese refractory eosinophilic chronic sinusitis epidemiological survey (JESREC) score, maxillary sinus score, ethmoid sinus score, CT total score and E/M[Lund-Mackay score ratio between ethmoid sinus and maxillary sinus] between the two groups (P < 0.05). The Novotels based on the history of asthma, peripheral blood EOS, peripheral blood Baso, maxillary sinus scores, and E/M have high predictive value for ECRSwNP, and the coordination index (C-index) value was 0.906, and the 95% confidence interval (CI) was 0.825–0.988.Conclusion Based on asthma history, EOS% in peripheral blood, Baso% in peripheral blood, maxillary sinus score and E/M nomogram has a high predictive value for ECRSwNP.