Abstract:The neuro-immune mechanism is a significant finding in the complex pathogenesis of allergic rhinitis. The central nervous system receives immune inflammatory signals from the periphery, integrates them and transmits them to the peripheral target organs, realizing the precise regulation of the immune system, which constitutes the central-peripheral bidirectional network of allergic rhinitis. The nerve terminals innervating the nasal mucosa interact with core immune cells such as mast cells, eosinophils, and type 2 resident lymphocytes by releasing neuropeptides to form a neuro-immune network, in which neuropeptides such as SP, CGRP, VIP, NMU, and NPY play an essential role. In recent years, there is more research progress about neuropeptides. This paper describes the neuro-immune mechanism of allergic rhinitis and the effects of the above neuropeptides to immune cells.