变应性鼻炎神经-免疫机制的研究进展
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1.山西医科大学;2.山西省气道炎性疾病神经免疫重点培育实验室

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国家自然科学基金(81870707,82171119)


The neuro-immune mechanism in allergic rhinitis
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1.Shanxi Medical University;2.Second hospital of Shanxi Medical University

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    摘要:

    变应性鼻炎发病机制复杂,神经-免疫机制是其重大发现。中枢神经系统接受来自外周的免疫炎症信号,将其整合并传出至外周靶器官,实现对免疫系统的精准调控,这构成变应性鼻炎的中枢-外周双向网络。支配鼻腔黏膜的神经末梢接受外界刺激后释放神经肽,与肥大细胞、嗜酸性粒细胞、2型固有淋巴细胞等核心免疫细胞相互作用,构成变应性鼻炎发病的外周神经-免疫网络,P物质、降钙素原基因相关肽、血管活性肠肽、神经介素U、神经肽Y等神经肽在其中发挥重要作用,且近年来又有较多进展。本文就变应性鼻炎的神经-免疫机制以及神经肽对免疫细胞的作用机制予以扼要介绍。

    Abstract:

    The neuro-immune mechanism is a significant finding in the complex pathogenesis of allergic rhinitis. The central nervous system receives immune inflammatory signals from the periphery, integrates them and transmits them to the peripheral target organs, realizing the precise regulation of the immune system, which constitutes the central-peripheral bidirectional network of allergic rhinitis. The nerve terminals innervating the nasal mucosa interact with core immune cells such as mast cells, eosinophils, and type 2 resident lymphocytes by releasing neuropeptides to form a neuro-immune network, in which neuropeptides such as SP, CGRP, VIP, NMU, and NPY play an essential role. In recent years, there is more research progress about neuropeptides. This paper describes the neuro-immune mechanism of allergic rhinitis and the effects of the above neuropeptides to immune cells.

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  • 收稿日期:2022-04-06
  • 最后修改日期:2022-05-07
  • 录用日期:2022-05-24
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