Abstract:Abstract: Objective To study the clinical characteristics of angioleiomyomas in the head and neck, and to provide reference for its clinical diagnosis and treatment. Methods From November 2009 to July 2021, the clinical records and follow-up data of 17 patients with angioleiomyoma of head and neck were analyzed retrospectively. Results 10 females and 7 males were included, with an average age of 49.5 years. The locations and numbers of cases of the tumors were as follows: auricle, six; cheek, six; nasal vestibule, one; nasal cavity, two; nasopharynx, one; vestibular groove on the left upper lip side, one. Fifteen patients showed painless masses, one located in the nasal vestibule complained of nasal obstruction and one located in the nasopharynx showed nasal obstruction with blood in the snot. Of the 17 patients, computed tomography were performed in 6 cases in total, and 4 of which showed vascularity of the mass with significant enhancement or heterogeneous enhancement after enhanced CT scan. The results of Fine needle aspiration in 5 cases were blood cells. Fifteen cases were confirmed by HE staining, and 2 cases were confirmed by HE staining and immunohistochemistry. According to the Morimoto’s classification, the histological subtypes were reported as solid in eight cases, venous in four, cavernous in four and solid-cavernous in one. All cases were treated by operation, and one case of a mass located in the nasopharynx with massive intraoperative bleeding, about 2000 ml, was stopped by electrocoagulation and compression. The rest of cases had no significant bleeding during surgery. All patients followed for 5 years averagely. All tumors were excised surgically without recurrence and malignant changes. Conclusion The clinical manifestations of angioleiomyomas in the head and neck are different. Histological and immunohistochemical tests can make a definite diagnosis of the disease. For large cases which were located in the space of the head and neck and difficult to remove completely, with the preoperative imaging test suggesting abundant blood supply to the tumor, vascular embolization of the tumor may be considered before surgery to reduce intraoperative bleeding. The prognosis of surgical excision is excellent.