嗜酸性粒细胞型慢性鼻窦炎小鼠模型构建的研究进展
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1.海军军医大学第二附属医院上海长征医院耳鼻咽喉头颈外科;2.海军军医大学第二附属医院上海长征医院 耳鼻咽喉头颈外科;3.海军军医大学药学院 药物化学教研室

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国家自然科学基金项目(面上项目,重点项目,重大项目)81870702


Research progress on models of eosinophilic chronic rhinosinusitis in mice
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Department of Otorhinolaryngology-Head and Neck Surgery,The Second Affiliated Hospital of Naval Medical University Shanghai Changzheng Hospital

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    摘要:

    慢性鼻-鼻窦炎是上呼吸道最常见的慢性炎症性疾病之一,其中的嗜酸性粒细胞型慢性鼻窦炎(ECRS)具有较高的治疗抵抗率及复发率,目前其病因及发病机制尚不明确。ECRS动物模型的成功构建是研究该疾病病理机制和治疗方案的理想手段。小鼠是常用的建模动物,但目前基础研究中仍缺乏一种公认成熟稳定的ECRS小鼠模型,成为对该病发病机制解析、药物筛选、精准治疗、诊断预后的关键瓶颈。本文回顾目前常用的ECRS小鼠模型,对其建模原理、方法步骤、评价指标及模型应用做一综述研究,以期为ECRS小鼠模型的成功建立及相关实验研究提供方法和理论依据。

    Abstract:

    Chronic rhinosinusitis is one of the most common chronic inflammatory diseases of the upper respiratory tract, in which eosinophilic chronic rhinosinusitis (ECRS) has a high treatment resistance rate and recurrence rate. At present, its etiology and pathogenesis are still unclear. The establishment and application of the animal model of ECRS is an ideal mean to study the pathogenesis and the exploration of new treatment. Mice are commonly used modeling animals, but there is still a lack of a recognized mature and stable murine model of ECRS in basic research, which has become a key bottleneck in the analysis of the pathogenesis, precise treatment, drug screening, diagnosis and prognosis of the disease. This paper reviews the commonly used murine models of ECRS and dose a summary study on their modeling principle, methods and steps, evaluation index and model application, in order to provide methods and theoretical basis for the successful establishment of the murine model and related experimental research.

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  • 收稿日期:2022-03-14
  • 最后修改日期:2022-04-08
  • 录用日期:2022-04-11
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