TRP通道在AHR神经免疫通路中的作用
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山西医科大学第二医院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Role of TRP channels in AHR neuroimmune pathway
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The second hospital of Shanxi Medical University

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    摘要:

    临床非特异性冷热刺激诱发无过敏原者上气道高反应表现、加重AR患者相关症状,依赖现有免疫药物治疗效果不佳,上述问题于临床顽固存在但尚无有效解决方案。瞬时受体电位(transient receptor potential,TRP)在上气道高反应疾病(upper airway hyper-responsiveness disease ,AHR)中的发现为其提供了新思路。神经-免疫通路是AHR发病机制的重要构成,TRP的表达和激发与其有着密不可分的关系,相关研究最终会解开此类症状具体发病机制的谜题,成为未来临床治疗及干预的新方向。本综述突出了AHR神经免疫通路发病机制的重点构成及相关TRP通道的作用,且TRPV1及TRPA1相关阻滞剂正逐步进入临床,TRPV4、TRPM8有望成为药物研究新热点。

    Abstract:

    Clinical nonspecific cold and heat stimulation induces upper airway hyperresponsiveness in patients without allergens, aggravates relevant symptoms in patients with AR, and the treatment effect of relying on existing immune drugs is poor. The above problems persist in clinic, but there is no effective solution. The discovery of transient receptor potential (TRP) in upper airway hyperresponsiveness disease (AHR) provides a new idea. Neuroimmune pathway is an important component of the pathogenesis of AHR. The expression and stimulation of TRP are closely related to it. Relevant research will eventually solve the mystery of the specific pathogenesis of such symptoms and become a new direction of clinical treatment and intervention in the future. This review highlights the key components of the neuroimmune pathway pathogenesis of AHR and the role of related TRP channels, and TRPV1, TRPA1 are gradually entering the clinic, TRPV4, TRPM8 are expected to become a new focus of drug research

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  • 收稿日期:2022-03-13
  • 最后修改日期:2022-04-05
  • 录用日期:2022-04-11
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