1.The People'2.'3.s Hospital of Suzhou New District,Suzhou
目的 探讨儿童过敏性鼻炎对认知功能及情绪的影响，并探索影响认知的危险因素。方法 选择该院2018年1月至2020年8月被诊断为过敏性鼻炎患儿223例，并招募220例年龄、性别、受教育程度相匹配的健康体检儿童作为对照组，受试人群均接受神经心理测试：蒙特利尔认知测评量表（MoCA） 、言语流畅性、数字广度、木块图、儿童社交焦虑量表 （SASC） 、儿童抑郁障碍自评量表（DSRSC） 。结果 过敏性鼻炎患儿 MoCA、言语流畅性、数字广度、木块图得分均较低（ P<0.05） ；SASC、DSRSC 得分均较高（ P<0.05） 。过敏性鼻炎组的 MoCA 得分与 SASC、DSRSC 及过敏性鼻炎严重程度呈负相关（ r=-0.346，-0.432，-0.479， P<0.01）。结论 过敏性鼻炎患儿的整体认知及言语、记忆、执行功能均受损， 并合并焦虑抑郁， 较高水平的焦虑、抑郁及中重度鼻炎是影响认知的危险因素。
Objective To evaluate the effects of anaphylactic rhinitis (AR) on cognitive function and emotion in children and the risk factors for cognitive impairment. Methods 223 Chidren with AR in The People's Hospital of Suzhou New District were enrolled from January 1, 2018 to August 30, 2020. Their clinical baseline data were collected. And 220 control healthy children with matched age, sex and educational level were enrolled. All subjects received the following neuropsychological tests: Montreal Cognitive Assessment (MoCA) scale, verbal fluency test, digit span test, block design test, Social Anxiety Scale for Children (SASC), and Depression Self-rating Scale for Children (DSRSC). Results Compared with the control group, the AR groups showed significantly lower scores of MoCA, verbal fluency, digit span, and block design (P<0.05) and significantly higher scores on SASC and DSRSC (P<0.05). In the AR group, MoCA score was negatively correlated with SASC score, DSRSC score, and the severity of AR ( r=-0.346，-0.432，-0.479, respectively; P<0.01). Conclusions Children with AR show impaired whole cognition, verbal fluency, memory, and executive function and have anxiety and depression. High levels of anxiety, depression, and severity of AR are risk factors for impaired cognitive function.