Micro-RNA在变应性鼻炎中的作用及其研究进展
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兰州大学第一医院

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Role and research progress of Micro-RNA in allergic rhinitis
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The first hospital of lanzhou university

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    摘要:

    变应性鼻炎(Allergic rhinitis,AR)是发生在鼻黏膜的变态反应性疾病,其特征是与血清IgE水平升高相关的Th2主导的免疫反应。它很大程度上影响个人社会生活,睡眠和工作,并增加了家庭和社会经济负担。目前在免疫疗法、鼻内类固醇、抗组胺药和肥大细胞稳定剂等AR的治疗方面取得了有效进展,但20%的AR患者并未表现出足够的主观和客观改善。因此,深入研究AR的发病机制,并开发用于治疗AR的新型制剂已是当务之急。Micro-RNA(miRNA)是一种基因表达调控小分子RNA,被认为与许多炎症性疾病有关,已经逐渐成为国内外学者研究的重点。本文系统综述了与AR密切相关的Micro-RNA,并对研究现状做了简要评析,指出了当前亟待深入研究的问题,希望能对该领域的发展提供一定的参考。

    Abstract:

    Allergic rhinitis (AR) is an allergic disease of the nasal mucosa and is characterized by a Th2-dominated immune response associated with elevated serum IgE levels. It greatly affects the social life, sleep and work of individuals, and increases the burden of family and social economy. Despite rapid progress in the treatment of AR, including immunotherapy, intranasal steroids and antihistamines, and mast cell stabilizers, 20% of AR patients no longer show sufficient subjective and objective improvement. Therefore, it is urgent to further study the pathogenesis of AR and develop new preparations for the treatment of AR. Micro-RNA (miRNA) is a kind of small molecule RNA regulating gene expression, which is believed to be related to many inflammatory diseases. It has gradually become the focus of research by scholars at home and abroad, and achieved some results. In this paper, AR-related micro-RNA was systematically summarized, and the current research status was briefly reviewed, and the problems urgently needed to be further studied were pointed out, hoping to provide some references for the development of this field.

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  • 收稿日期:2022-02-24
  • 最后修改日期:2022-03-31
  • 录用日期:2022-04-11
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