Abstract:The fascial structure of the skull base is one of the most complex structures in the skull base region, which separates many fascial spaces. It is helpful for the surgeon to understand the anatomical layers from the lateral to the midline of the skull base in the traditional open approach. It also plays an important role as anatomical landmark in skull base surgery. In the past 20 years, there have been major changes in the techniques and concepts of skull base surgery. And the techniques and concepts of skull base surgery have changed from the previous open approach surgery to the mainstream endoscopic transnasal or transoral surgery. However, there are still many controversies about the structure of the skull base fascia, and its applied anatomy and clinical application value in endoscopic transnasal or transoral surgery are still in the exploratory stage in exploratory stage. The purpose of this paper is to review the anatomical research progress of the skull base fascia structure in recent 20 years.