慢性嗜酸性粒细胞型鼻窦炎的研究进展

Research progress on chronic eosinophilic sinusitis

摘要:

慢性嗜酸性粒细胞型鼻窦炎（ECRS）是以嗜酸性粒细胞浸润为特征的呼吸道黏膜炎性疾病。嗜酸性粒细胞是一种特殊的炎症细胞，与Th2型免疫反应密切相关。促进和维持ECRS患者嗜酸性炎症的机制主要有以下4个方面：白介素-5（IL-5）调控嗜酸性粒细胞的生物学效应、嗜酸性粒细胞胞外陷阱的免疫调节作用、细胞自噬调节和纤维蛋白异常沉积。ECRS表现出病因复杂、难治愈和易复发等特点，嗜酸性粒细胞在ECRS的发生发展中扮演着重要的角色。本文就国内外最新报道进行综述，以期为ECRS的治疗提供理论依据。

Abstract:

Eosinophilic chronic rhinosinusitis(ECRS) is an inflammatory disease of respiratory mucosa, which is characterized by eosinophil infiltration. Eosinophil is a special type of inflammatory cell, which is closely related to Th2 type immune response.There are four main mechanisms that promote and maintain eosinophilic inflammation in ECRS patients:the biological effects of interleukin-5 (IL-5) in regulating eosinophils, immunomodulatory effects of eosinophilic extracellular traps, autophagy regulation and abnormal fibrin deposition. ECRS is characterized by complex etiology, difficult cure and easy recurrence.Eosinophils play an important role in the occurrence and development of ECRS.This article reviews the latest reports at home and abroad in order to provide theoretical basis for the treatment of ECRS.