T细胞在慢性鼻窦炎中的作用机制
作者:

Inflammatory mechanisms of T cells in chronic sinusitis
Author:
  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • | |
    摘要:

    慢性鼻窦炎(CRS)的基本病理特征为鼻窦黏膜的慢性炎症反应,其发病机制尚未完全阐明,但目前认为免疫应答紊乱及免疫细胞分化异常密切相关。已有研究表明,各种亚型的T细胞及其分泌的炎性因子都对CRS的发生发展具有一定的推动作用。Th1细胞介导细胞免疫,Th2细胞介导体液免疫,CRS患者体内存在Th1和Th2细胞比例失衡,当Th2免疫活性过度增高,造成Th2细胞浸润鼻黏膜局部,Th2细胞分泌的IL-4在鼻黏膜组织和血清中的含量明显增加。IL-4可以对Th1细胞产生抑制作用,让T细胞与B细胞的相互作用得到增强,进一步促进体液免疫应答。本文重点对CD4+T细胞、CD8+T细胞在CRS中的发生机制进展进行综述分析。

    Abstract:

    The basic pathological feature of chronic rhinosinusitis(CRS) is chronic inflammatory reaction of the nasal sinus mucosa. The pathogenesis of CRS has not been fully elucidated, but it is believed that the disorder of immune response and abnormal differentiation of immune cells are closely related.Previous studies have shown that various subtypes of T cells and their secretion of inflammatory factors play a certain role in promoting the occurrence and development of CRS. Th1 cells mediate cellular immune responses and Th2 cells mediated humoral immunity.The proportion of Th1 and Th2 cells in CRS patients is unbalanced. When the Th2 immune activity was excessively increased, Th2 cells infiltrated into the nasal Mucosa; the levels of IL-4, secreted by Th2 cells, were significantly increased in Nasal Mucosa and serum. IL-4 can inhibit Th1 cells, and enhance the interaction between t cells and B cells, which will further promote the humoral immune response. In this paper, the mechanism of CD4+T cells and CD8+T cells in CRS was reviewed and analyzed.

    网友评论
    网友评论
    分享到微博
    发 布
    参考文献
    [1] Klimek L, Casper I, Siemer S, et al.T-Zell-Immunreaktionen bei chronisch entzündlichen Erkrankungen der nasalen Schleimhäute[J].HNO, 2019, 67(11):881-892.
    [2] 房红娟,李晓瑞,马辉娟,等.老年慢性鼻窦炎患者血清IL-2、IL-6、TNF-α水平与黏膜组织重塑的关系[J].成都医学院学报,2021:1-8.
    [3] Raphael I, Nalawade S, Eagar TN, et al. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases[J].Cytokine, 2015, 74(1):5-17.
    [4] Kumar BV,Connors TJ, Farber DL. Human T cell development, localization, and function throughout life[J].Immunity, 2018, 48(2):202-213.
    [5] Brummelman J, Pilipow K, Lugli E. The single-cell phenotypic identity of human CD8+ and CD4+ T cells[J]. Int Rev Cell Mol Biol, 2018, 341:63-124.
    [6] Bhattacharyya ND, Feng CG. Regulation of T helper cell fate by TCR signal strength[J]. Front Immunol, 2020, 11:624.
    [7] Soderquest K, Hertweck A, Giambartolomei C, et al. Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease[J]. PLoS Genet, 2017,13(2):e1006587.
    [8] Fenimore J, A Young H. Regulation of IFN-γ Expression[J]. Adv Exp Med Biol, 2016,941:1-19.
    [9] 王耀洁,李春花,刘红兵.IL-8在慢性鼻窦炎中的表达及作用[J].临床耳鼻咽喉头颈外科杂志,2021,35(8):765-768.
    [10] Mandik-Nayak L. Differential roles of IDO1 and IDO2 in T and B cell inflammatory immune responses[J]. Front Immunol,2020,18(11):1861.
    [11] Bal SM, Bernink JH, Nagasawa M, et al. IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs[J]. Nat Immunol, 2016,17(6):636-645.
    [12] 孙燕,罗志强.嗜酸性粒细胞与慢性鼻-鼻窦炎伴鼻息肉的相关性研究进展[J].中国耳鼻咽喉颅底外科杂志,2019,127(1):104-108.
    [13] Patel NN, Kohanski MA, Maina IW, et al. Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps[J]. Int Forum Allergy Rhinol, 2018,9:10.
    [14] 徐杨.通过对血清中IL-4、5、6、TGF-β1的表达的研究探讨醒窍汤对慢性鼻-鼻窦炎不伴息肉术后的作用机制[D].南京:南京中医药大学,2019.
    [15] Chen J, Caspi RR, Chong WP. IL-20 receptor cytokines in autoimmune diseases[J]. J Leukoc Biol, 2018,104(5):953-959.
    [16] Miyake MM, Nocera A, Miyake MM. P-glycoprotein and chronic rhinosinusitis[J]. World J Otorhinolaryngol Head Neck Surg, 2018,4(3):169-174.
    [17] 李艺敏,谭国静,江雨,等.TGF-β1/Smads通路在体外培养的鼻息肉组织重构中的作用[J].上海交通大学学报(医学版),2019,39(7):737-743.
    [18] 姜晓丹. Th17及其细胞因子在不同病理特征慢性鼻-鼻窦炎鼻息肉中作用机制的研究[D].吉林:吉林大学,2011.
    [19] Palmer C, Mulligan JK, Smith SE, et al. The role of regulatory T cells in the regulation of upper airway inflammation[J]. Am J Rhinol Allergy, 2017,31(6):345-351.
    [20] 安丽,闫娟,张杰,等.慢性鼻窦炎伴鼻息肉患者血清25(OH) D和Tregs的表达水平及临床意义[J].海南医学,2020,31(22):2911-2914.
    [21] 李帅祥,李霞,陈晓红,等.Notch通路在鼻息肉中的表达及其与调节性T细胞表达和嗜酸粒细胞浸润的相关性研究[J].中华耳鼻咽喉头颈外科杂志,2021,56(2):124-132.
    [22] 王娅,王悦,马永明,等.Th9和Th17及Treg细胞在鼻息肉发病中的研究与探讨[J].临床耳鼻咽喉头颈外科杂志,2016,30(4):277-281.
    [23] 陈布衣,张昌明.慢性鼻窦炎黏膜组织中Eotaxin-3、Foxm1表达量与p38MAPK/NF-κB、炎症因子表达的相关性[J].海南医学院学报,2017,23(13):1874-1876.
    [24] Wang J, Qiu L, Chen Y, et al. Sublingual immunotherapy increases Treg/Th17 ratio in allergic rhinitis[J]. Open Med (Wars). 2021,16(1):826-832.
    [25] Lee GR. The balance of Th17 versus Treg cells in autoimmunity[J]. Int J Mol Sci, 2018,19(3):730.
    [26] Ickrath P, Sprügel L, Beyersdorf N, et al. Detection of candida albicans-specific CD4+ and CD8+ T cells in the blood and nasal mucosa of patients with chronic rhinosinusitis[J]. J Fungi (Basel), 2021, 7(6):403.
    [27] 徐翔,刘琼,刘蓓,等.鼻内镜术后鱼腥草滴鼻液与糠酸莫米松鼻喷雾剂联合局部应用对鼻黏膜CD4+及CD8+ T细胞分布的影响[J].中国药师,2019,22(4):708-711.
    引证文献
引用本文

张婧,张东利,王旻. T细胞在慢性鼻窦炎中的作用机制[J].中国耳鼻咽喉颅底外科杂志,2022,28(3):106-110

复制
分享
文章指标
  • 点击次数:705
  • 下载次数: 549
历史
  • 收稿日期:2021-10-13
  • 在线发布日期: 2022-07-04
温馨提示

本刊唯一投稿网址:www.xyosbs.com
唯一办公邮箱:xyent@126.com
编辑部联系电话:0731-84327210,84327469
本刊从未委托任何单位、个人及其他网站代理征稿及办理其他业务联系,谨防上当受骗!

关闭