Abstract:The basic pathological feature of chronic rhinosinusitis(CRS) is chronic inflammatory reaction of the nasal sinus mucosa. The pathogenesis of CRS has not been fully elucidated, but it is believed that the disorder of immune response and abnormal differentiation of immune cells are closely related.Previous studies have shown that various subtypes of T cells and their secretion of inflammatory factors play a certain role in promoting the occurrence and development of CRS. Th1 cells mediate cellular immune responses and Th2 cells mediated humoral immunity.The proportion of Th1 and Th2 cells in CRS patients is unbalanced. When the Th2 immune activity was excessively increased, Th2 cells infiltrated into the nasal Mucosa; the levels of IL-4, secreted by Th2 cells, were significantly increased in Nasal Mucosa and serum. IL-4 can inhibit Th1 cells, and enhance the interaction between t cells and B cells, which will further promote the humoral immune response. In this paper, the mechanism of CD4+T cells and CD8+T cells in CRS was reviewed and analyzed.
