Abstract:Objective To explore the the treatment and prognosis of patients with traumatic interhemispheric subdural hematoma (TISH).Methods the clinical data of 29 TISH patients admitted to Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from August 2014 to May 2019 were retrospectively analyzed. Short-term outcomes were assessed by the Glasgow Outcome Scale (GOS) at two weeks after treatment. GOS 1~3 was poor, and GOS 4~5 was good.Results The good curative effect was achieved in 20 cases (69.0%), while the poor outcome was identified in 9 cases (31.0%). The mean GCS was (14.6±0.7) points in good outcome group and (9.4±2.2) points in the poor treatment group at two weeks after treatment, the difference between the two groups was statistically significant (P<0.001). Univariate analysis demonstrated various factors affecting the TISH outcome including cerebral contusion (0.032), GCS score at admission (P<0.001), GCS score decreased during hospitalization (P=0.049), and extreme GCS value during hospitalization (P<0.001), treatment (P=0.016) and surgical approach (P<0.05). In severe TISH patients (GCS ≤ 8), 7 patients were treated surgically and three cases received non-surgical treatment. The short-term outcome in surgery group, 4 cases had good prognosis, and 3 cases had poor prognosis.Conclusion The incidence of TISH was rare. Most TISH was mild illness, who might achieve a good outcome by medication treatment. Similarly, a good outcome could be obtained by neuro-monitoring and neurosurgical treatment in some severe cases with delayed hemorrhage, increased intracranial pressure and nerve dysfunction.