Abstract:Circular RNA is a class of endogenous non-coding RNAs without a 5’ methylated cap structure and a 3’ poly-adenosine tail,which is characterized by a covalently closed loop structure. Because of its special circular structures, it has a higher tolerance to exonuclease digestion, which is more stable than linear RNA. circRNA is involved in a wide range of biological processes, which plays an important role in the occurrence and development of various tumors. circRNA may become an ideal therapeutic target for tumors. It has been reported that the abnormal expression of circRNA is closely related to the occurrence and development of laryngeal cancer. In this paper, the domestic and foreign literatures related to circRNA and laryngeal cancer were reviewed, which may provide reference for gene-targeted therapies and biomarkers of laryngeal carcinoma.
