Abstract:Objective To analyze a case of hemorrhagic fever with renal syndrome (HFRS) and the related literatures were reviewed in order to improve the clinicians’ understanding of HFRS. Methods The clinical data of HFRS patients admitted for epistaxis in February 2020 were retrospectively analyzed.The epidemiology, pathogenesis, clinical manifestations, diagnosis and treatment of this disease were discussed and analyzed in combination analyzed in combination with the relevant domestic and foreign literatures. Results The patient was hospitalized for epistaxis without other symptoms.The patient’s condition deteriorated rapidly after admission. After further examination and multi-department consultation, the patient was diagnosed as HFRS and recovered after active treatment. Conclusions Epistaxis may be the first manifestation of HFRS. Patients with clinical epistaxis should be alert to the existence of HFRS.Clinical patients should pay attention to the symptoms of atypical cases and pay attention to the basic test indicators to avoid misdiagnosis and mistreatment.