Abstract:Objective To investigate and summarize the method and effect of protecting sphenoparietal sinus drainage vein in the operation of middle cranial fossa meningioma. Methods The clinical data of 27 patients with middle cranial fossa meningiomas who underwent surgery from June 2008 to June 2019 were analyzed retrospectively. There were 10 males and 17 females, aged from 30 to 67 years, with an average age of 55.5 years. The onset time was 4 months to 3 years. 15 cases had superior drainage of sphenoparietal sinus and 12 cases had non dominant drainage. Tumor resection was performed in all 27 patients via frontal-temporal interfascial approach. Results Simpson Grade Ⅱ resection was achieved in 24 cases and Simpson Grade Ⅲ resection in 3 with no deaths.3 non dominant drainage veins were cut off due to tumor wrapping and adhesion. One case underwent secondary operation to remove the bone flap due to edema. All the patients had been fllowed-up postoperatively for 2 to 13 years with an average of 5.5 years. No tumor recurrence occurred. Conclusion Meningiomas in the middle cranial fossa often involved the drainage vein of the sphenoparietal sinus. The venous drainage should be evaluated carefullly before operation.We should pay more attention to the protection of the vein, sharply separate and dissect the drainage vein, so as to avoid the occurrence of brain edema postoperatively.