鼻中隔IgG4相关性疾病1例
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广东省中医院

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IgG4 related disease involving the nasal septum:a case report
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Guangdong Provincial Hospital of Chinese Medicine

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    摘要:

    鼻中隔IgG4相关性疾病是一种慢性炎症纤维化疾病,以鼻中隔肿块伴或不伴其他脏器受累为主要表现,目前该病发病机制不明,具有一定程度的骨质侵袭性,因而容易被误诊为恶性肿瘤。本文报道了1例鼻中隔鼻中隔IgG4相关性疾病的诊疗经过。经手术切除石蜡病理明确诊断,后以激素合并免疫制剂维持治疗。术后随访近2年,鼻中隔肿物未见复发,无其它脏器受累。临床上对于鼻腔不明性质的占位性病变,应将外周血IgG4列入常规初筛方法,病理加做免疫组化排除其他病变,尽量做到早诊早治。

    Abstract:

    Nasal septum IgG4-related disease is a chronic inflammatory and fibrotic disease. The main manifestation is nasal septal mass with or without involvement of other organs. At present, the pathogenesis of the disease is unknown, and it has a certain degree of bone invasiveness, so it is easy to be misdiagnosed as Malignant tumors. This article reports the diagnosis and treatment of a case of IgG4 related diseases of the nasal septum. After surgical excision of paraffin pathology, the diagnosis was confirmed, and then maintenance treatment with hormones combined with immune preparations. After the follow-up for nearly 2 years, there was no recurrence of the nasal septum mass, and no other organs were involved. Clinically, for space-occupying lesions of unknown nature in the nasal cavity, peripheral blood IgG4 should be included in the routine primary screening method, pathology should be added to immunohistochemistry to exclude other lesions, and early diagnosis and treatment should be achieved as soon as possible.

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  • 收稿日期:2021-10-31
  • 最后修改日期:2021-12-07
  • 录用日期:2021-12-09
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