T细胞在慢性鼻窦炎中的作用
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内蒙古医科大学第四附属医院

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The role of T cells in chronic rhinosinusitis
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内蒙古医科大学第四附属医院

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    摘要:

    慢性鼻窦炎(CRS)的基本病理特征为鼻窦黏膜的慢性炎症反应,其发病机制尚未完全阐明,但目前认为免疫应答紊乱及免疫细胞分化异常密切相关。已有研究表明,各种亚型的T细胞及其分泌的炎性因子。Th1细胞介导细胞免疫,Th2细胞介导体液免疫,CRS患者体内存在Th1和Th2细胞比例失衡,当Th2免疫活性过度增高,造成Th2细胞浸润鼻黏膜局部,Th2细胞分泌的IL-4在鼻黏膜组织和血清中的含量明显增加。IL-4可以对Th1细胞产生抑制作用,让T细胞与B细胞的相互作用得到增强,进一步促进体液免疫应答。本文针对CD4+T细胞、CD8+T细胞在CRS中的发生机制进展进行综述分析。

    Abstract:

    The basic pathological feature of chronic rhinosinusitis is chronic inflammatory reaction of the nasal sinus Mucosa, the pathogenesis of which has not been fully elucidated, but it is believed that the disturbance of immune response and abnormal differentiation of immune cells are closely related. Studies have shown that various subtypes of t cells and their secretion of inflammatory factors. TH1 cells mediated cellular immunity, Th2 cells mediated humoral immunity, the proportion of Th1 and Th2 cells was unbalanced in CRS patients. When the Th2 immune activity was excessively increased, Th2 cells infiltrated the nasal Mucosa, the levels of IL-4 secreted by Th2 cells in Nasal Mucosa and serum were significantly increased. IL-4 can inhibit TH1 cells, enhance the interaction between t cells and B cells, and further promote the humoral immune response. In this paper, the mechanism of CD4+T cells and CD8+T cells in CRS is reviewed.

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  • 收稿日期:2021-10-13
  • 最后修改日期:2021-11-20
  • 录用日期:2021-11-24
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