外周血中性粒细胞与淋巴细胞比率及血小板与淋巴细胞比率对喉鳞状细胞癌预后价值的研究进展

Research progress on prognostic value of peripheral blood NLR and PLR in laryngeal squamous cell carcinoma

摘要:

喉鳞状细胞癌（LSCC）是头颈鳞状细胞癌最常见类型之一，由多种致癌因素共同影响所致且预后欠佳。LSCC预后因素包括个体状况、原发肿瘤大小、淋巴结受累情况、有无远处转移和人乳头状瘤病毒（HPV）感染等，均不能准确评估LSCC预后，因此，探寻新的指标显得尤为重要。在肿瘤的发生、发展、转移过程中，炎症因子起到了至关重要的作用，其中外周血中性粒细胞/淋巴细胞比率（NLR）、血小板/淋巴细胞比率（PLR）对LSCC预后价值较高且备受关注，因此本文将探讨NLR、PLR与LSCC预后价值的关系，为临床诊疗提供参考。

Abstract:

Laryngeal squamous cell carcinoma (LSCC) is one of the most common types of head and neck squamous cell carcinoma. LSCC with a poor prognosis is caused by multiple carcinogenic factors. The prognostic factors of LSCC include individual physical condition, primary tumor size, lymph node involvement, distant metastasis and human papillomavirus (HPV) infection, etc., which cannot accurately evaluate the prognosis of LSCC. Therefore, it is particularly important to explore new indicators of LSCC. Inflammatory factors play a crucial role in the occurrence, development and metastasis of tumors. Among them, Neutrophils to lymphocytes ratio (NLR) and platelets to lymphocytes ratio (PLR) in peripheral blood have high prognostic value for LSCC, which have attracted much attention. Therefore, this paper will discuss the relationship between the prognostic value of NLR, PLR and LSCC, which has reference value for clinical diagnosis and treatment of LSCC.