Abstract:Allergic rhinitis (AR) is a chronic non-infectious inflammation of the nasal mucosa. AR is a hypersensitive reaction of nasal mucosa mediated by specific immunoglobulin E (IgE) and involving a variety of inflammatory cells (such as mast cells and basophils, etc.) induced by the body's exposure to allergens. Histamine plays an important role in the pathogenesis of AR, which is the core mediator of clinical symptoms such as nasal itching, sneezing, and runny nose. Antihistamine drugs usually block histamine binding to histamine-associated receptors by antagonizing them, thus affecting the process of allergy. Therefore, the application of antihistamines in AR treatment is becoming more and more important and widespread. This article mainly reviewed the mechanism and treatment progress of antihistamines in AR, and discussed its application value in AR.
