慢性鼻窦炎术后局部激素不同给药方式的研究进展

Research progress of local glucocorticoids administered in different ways after endoscopic sinus surgery for chronic sinusitis

摘要:

慢性鼻窦炎（CRS）是一种高度异质性疾病，其中CRS伴鼻息肉以及以嗜酸性粒细胞浸润为主的CRS等临床难治性鼻窦炎预后最差，严重影响着人们的生活质量和身心健康。鼻用糖皮质激素一直被推荐为CRS术后的一线用药，并具有良好的临床疗效。近年来，国内外学者针对CRS术后局部激素的给药方式相继开展了大量研究，本文系统地总结了鼻喷剂、鼻滴剂、鼻腔盥洗、鼻腔雾化吸入及鼻腔激素植入物等术后局部激素的给药方式及最新研究进展，回顾了国内外相关文献并加以综述，以期为临床治疗提供参考。

关键词:慢性鼻窦炎;鼻用糖皮质激素;给药方式;个体化治疗

Abstract:

Chronic rhinosinusitis (CRS) is a highly heterogeneous disease. CRS with nasal polyps and CRS with eosinophil infiltration are the main clinical refractory sinusitis with the worst prognosis, which seriously affect people's quality of life and physical and mental health. Nasal glucocorticoid has been recommended as a first-line drug for CRS after endoscopic sinus surgery, and achieved good results. In recent years, domestic and foreign scholars have carried out a large number of studies on different ways of administration of local glucocorticoids after endoscopic sinus surgery for chronic sinusitis. This paper systematically summarized and reviewed the relevant domestic and foreign literatures to provide reference for clinical treatment.

Key words:Chronic rhinosinusitis;Nasal glucocorticoid;Method of administration;Individualized treatment