头颈部恶性肿瘤类器官研究现状及应用

Research status and application of organoids in head and neck malignant tumor

摘要:

在精准医疗时代，头颈恶性肿瘤类器官培养技术能够维持肿瘤细胞的高度异质性，更好地模拟体内的肿瘤微环境，培养效率高、耗时少，同时具备肿瘤细胞系可进行遗传操作的优点和小鼠PDX模型的三维复杂系统特性，可作为测试肿瘤药物和个体化肿瘤疗法的新型平台，利于致癌基因建模、靶基因发现和个体化药物敏感性检测，可用于头颈恶性肿瘤的精准治疗。本文就头颈恶性肿瘤个体化类器官在精准医学时代背景下的研究现状及其潜在的临床应用前景进行综述。

Abstract:

In the era of precision medicine, organoid culture of head and neck malignant tumor can maintain high heterogeneity of tumor cells, which can better simulate the tumor microenvironment in vivo, with high efficiency and less time consumption.The organoid culture technology for head and neck malignant tumor has the advantages of genetic manipulation of tumor cell lines and the three-dimensional complex system characteristics of mouse PDX model. The organoid culture technology of head and neck malignant tumor can be used as a new platform for testing tumor drugs and individualized cancer therapies. Organoid culture technology of head and neck malignant tumor is beneficial to modeling of oncogenes, discovery of target genes and detection of individual drug sensitivity, which can be used for accurate treatment of head and neck malignant tumor. This paper reviewed the research status and potential clinical application of personalized organoids in head and neck malignant tumor under the background of precision medicine.